Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress
نویسندگان
چکیده
منابع مشابه
Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress
BACKGROUND Naja naja atra venom (NNAV) displays diverse pharmacological actions including analgesia, anti-inflammation and immune regulation.In this study, we investigated the effects of NNAV on pulmonary fibrosis and its mechanisms of action. METHODS To determine if Naja naja atra venom (NNAV) can produce beneficial effects on pulmonary fibrosis, two marine models of pulmonary fibrosis were ...
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Previous studies reported that Naja naja atra venom (NNAV) inhibited inflammation and adjuvant arthritis. Here we investigated the role of NNAV in regulation of immune responses in mice. Oral administration of NNAV to normal mice showed significant increase in natural killer cell activity, B lymphocyte proliferation stimulated by lipopolysaccharides, and antibody production in response to sheep...
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Chronic kidney disease (CKD) becomes a global health problem with high morbidity and mortality. Adriamycin- (ADR-) induced rodent chronic nephropathy is a classic experimental model of human minimal lesion nephrotic syndrome. The present study investigated the effect of cobrotoxin (CTX) on ADR-induced nephropathy. Rats were given 6 mg/kg ADR once through the tail vein to replicate ADR nephropat...
متن کاملAnti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom
Naja naja atra venom (NNAV) is composed of various proteins, peptides, and enzymes with different biological and pharmacological functions. A number of previous studies have reported that NNAV exerts potent analgesic effects on various animal models of pain. The clinical studies using whole venom or active components have confirmed that NNAV is an effective and safe medicine for treatment of ch...
متن کاملAnti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra
BACKGROUND Neurotoxin-Nna (NT), an analgesic peptide separated from the venom of Naja naja atra, has reported to have an exceptional specificity to block transmission of the nerve impulse by binding to the α- subunit of the nicotinic acetylcholine receptor in the membrane. However, little information is available on the anti-inflammatory effects of NT. Therefore, the anti-inflammatory activity ...
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ژورنال
عنوان ژورنال: BMC Complementary and Alternative Medicine
سال: 2014
ISSN: 1472-6882
DOI: 10.1186/1472-6882-14-461